The most common way to set up multiple storage drives is to configure a RAID array. Using RAID to combine multiple drives into a larger virtual drive will generally keep systems up and running despite ...
Pick the wrong RAID level, and you might end up losing all your data ...
I've been using 2x 4TB drives in RAID 1 for the past 8 years or so as my main data store on the local PC (pictures, videos and documents). Also sync it to my NAS and do an off-site cloud backup.